J Wound Manag Res.  2024 Feb;20(1):9-16. 10.22467/jwmr.2023.02817.

A Glimpse of Urine Stromal Cells-Derived Exosomes Containing Deleted in Malignant Brain Tumors 1: A Critical Factor in Wound Healing

• Shojaeian A

• KMID: 2552925
• DOI: http://doi.org/10.22467/jwmr.2023.02817

Abstract

Exosomes are small extracellular vesicles released by a range of cells, including mesenchymal stromal/stem cells (MSCs), immune cells, cancerous cells, etc. These particles contain biomolecules such as DNA, microRNA, messenger RNA, protein, and lipid, and play a vital role in establishing cellular communication. After reaching the target cells, the particles cause changes in function, fate, morphology, differentiation, and growth. Exosomes released from a variety of sources have the ability to influence the behavior of cells involved in wound healing, enhance neovascularization, promote collagen deposition, reduce inflammation, and quicken the healing process. According to new research, endothelial cell adhesion, migration, proliferation, vascular repair, and angiogenesis are all accelerated during the wound healing process when deleted in malignant brain tumors 1 (DMBT1) is used as an active stimulant. This article will review DMBT1 protein as one of the major elements of exosomes from human urine-derived MSCs.

Keyword

Small extracellular vesicles; Exosomes; DMBT1 protein; Wound healing