Maxillofac Plast Reconstr Surg.
2023;45(1):15. 10.1186/s40902-023-00383-9.
Nanomedicine and nanoparticle‑based delivery systems in plastic and reconstructive surgery
- Affiliations
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- 1MD‑PhD (Molecular Medicine) Program, College of Medicine, University of the Philippines Manila, Ermita, Manila 1000, Philippines
- 2College of Medicine, University of the Philippines Manila, Ermita, Manila 1000, Philippines
- 3Department of Otolaryngology ‑ Head and Neck Surgery, Section of Craniomaxillofacial Plastic and Restorative Surgery, College of Medicine ‑ Philippine General Hospital, University of the Philippines Manila, Ermita, Manila 1000, Philippines
- 4Department of Physiology, College of Medicine, University of the Philippines Manila, Ermita, Manila 1000, Philippines
- 5Department of Biology, College of Science, De La Salle University, Manila 1004, Philippines
- 6Swedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden
- KMID: 2552538
- DOI: http://doi.org/10.1186/s40902-023-00383-9
Abstract
- Background
Nanotechnology and nanomedicine are rising novel fields in plastic and reconstructive surgery (PRS). The use of nanomaterials often goes with regenerative medicine. Due to their nanoscale, these materials stimulate repair at the cellular and molecular levels. Nanomaterials may be placed as components of nanocomposite polymers allowing enhancement of overall biochemical and biomechanical properties with improved scaffold properties, cellular attachment, and tissue regeneration. They may also be formulated as nanoparticle-based delivery systems for controlled release of signal factors or antimicrobials, for example. However, more studies on nanoparticle-based delivery systems still need to be done in this field. Nanomaterials are also used as frameworks for nerves, tendons, and other soft tissues. Main body In this mini-review, we focus on nanoparticle-based delivery systems and nanoparticles targeting cells for response and regeneration in PRS. Specifically, we investigate their roles in various tissue regeneration, skin and wound healing, and infection control. Cell surface-targeted, controlled-release, and inorganic nanoparticle formulations with inherent biological properties have enabled enhanced wound healing, tumor visualization/imaging, tissue viability, and decreased infection, and graft/transplantation rejection through immunosuppression.
Conclusions
Nanomedicine is also now being applied with electronics, theranostics, and advanced bioengineering technologies. Overall, it is a promising field that can improve patient clinical outcomes in PRS.
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