Nucl Med Mol Imaging.  2008 Oct;42(5):337-346.

Nanomedicine: Drug Delivery Systems and Nanoparticle Targeting

• Youn H
• Kang KW
• Chung JK
• Lee DS

Abstract

Applications of nanotechnology in the medical field have provided the fundamentals of tremendous improvement in precise diagnosis and customized therapy. Recent advances in nanomedicine have led to establish a new concept of theragnosis, which utilizes nanomedicines as a therapeutic and diagnostic tool at the same time. The development of high affinity nanoparticles with large surface area and functional groups multiplies diagnostic and therapeutic capacities. Considering the specific conditions related to the disease of individual patient, customized therapy requires the identification of disease target at the cellular and molecular level for reducing side effects and enhancing therapeutic efficiency. Well-designed nanoparticles can minimize unnecessary exposure of cytotoxic drugs and maximize targeted localization of administrated drugs. This review will focus on major pharmaceutical nanomaterials and nanoparticles as key components of designing and surface engineering for targeted theragnostic drug development.

Keyword

nanomedicine; nanoparticle; drug delivery system; targeting; PEGylation; theragnosis

MeSH Terms

Drug Delivery Systems
Humans
Nanomedicine
Nanoparticles
Nanostructures
Nanotechnology