Dement Neurocogn Disord.
2024 Jan;23(1):54-66. 10.12779/dnd.2024.23.1.54.
The Usefulness of 18 F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis
- Na S
1 - Kang DW2
- Kim GH3
- Kim KW4
- Kim Y5
- Kim HJ6
- Park KH7
- Park YH8
- Byeon G9
- Suh J10
- Shin JH11
- Shim Y12
- Yang Y13
- Um YH14
- Oh Si15
- Wang SM16
- Yoon B17
- Yoon HJ18
- Lee SM19
- Lee J20
- Lee JS15
- Rhee HY21
- Lim JS22
- Jung YH23
- Chin J24
- Hong YJ25
- Jang H26
- Choi H27
- Choi M28
- Jang JW5
- oboKDA
- Affiliations
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- 1Department of Neurology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
- 2Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 3Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
- 4Department of Neurology, Jeonbuk National University Hospital, Jeonbuk National University College of Medicine, Jeonju, Korea.
- 5Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea.
- 6Department of Neurology, Hanyang University Hospital, College of Medicine, Hanyang University, Seoul, Korea.
- 7Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Korea.
- 8Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
- 9Department of Psychiatry, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea.
- 10Department of Neurology, National Medical Center, Seoul, Korea.
- 11Dr Shin’s Neurology Clinic, Wonju, Korea.
- 12Department of Neurology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 13Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University School of Medicine, Cheonan, Korea.
- 14Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
- 15Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.
- 16Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 17Department of Neurology, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.
- 18Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
- 19Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
- 20Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
- 21Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea.
- 22Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 23Department of Neurology, Myungji Hospital, Goyang, Korea.
- 24Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 25Department of Neurology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.
- 26Department of Neurology, Seoul National University Hospital, Seoul, Korea.
- 27Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
- 28Division of Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea.
- KMID: 2552358
- DOI: http://doi.org/10.12779/dnd.2024.23.1.54
Abstract
- Background and Purpose
Dementia subtypes, including Alzheimer’s dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of 18 F-Fluorodeoxyglucose Positron Emission Tomography ( 18 F-FDG PET) in differentiating these subtypes for precise treatment and management.
Methods
A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of 18 F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the goldstandard clinical diagnosis for dementia subtypes.
Results
From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88–0.98) and specificity was 0.84 (95% CI, 0.70–0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70–0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80–0.91) and the specificity was 0.88 (95% CI, 0.80–0.91). The studies mostly used case-control designs with visual and quantitative assessments.
Conclusions
18 F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.
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