Med Lasers.
2023 Jun;12(2):71-83. 10.25289/ML.23.021.
Boron delivery systems for enhanced boron neutron capture therapy: a comprehensive review
- Affiliations
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- 1Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea
- 2Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea
- 3College of Science and Technology, Dankook University, Cheonan, Republic of Korea
- 4Department of Pre-Medical Course, College of Medicine, Dankook University, Cheonan, Republic of Korea
- 5Division of Natural Sciences, The National Academy of Sciences, Seoul, Republic of Korea
- 6International Research Frontier Initiative (IRFI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan
- KMID: 2551136
- DOI: http://doi.org/10.25289/ML.23.021
Abstract
- Boron neutron capture therapy (BNCT) is a promising cancer-treatment strategy that involves the induction of nuclear fission reactions via the interaction of low-energy thermal neutrons with boron ( 10B), enabling selective tumor-cell apoptosis. For BNCT to be effective, achieving a high degree of localization of 10B atoms within the tumor cells is crucial. Currently, the clinical use of the two U.S. Food and Drug Administration (FDA)-approved drugs for BNCT, sodium mercaptoundecahydro-closo-dodecaborate (BSH) and boronophenylalanine (BPA), is restricted by their low uptake and low tumor-to-blood selectivity. Ongoing efforts are focused on developing high-uptake boron delivery agents with pharmacokinetic characteristics that enable high-efficiency BNCT. This review provides a comprehensive overview of the recent developments in boron delivery strategies for BNCT.
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