Prog Med Phys.  2020 Sep;31(S1):S56.

Preliminary Study for Dosimetry of Boron Neutron Capture Therapy with Polymer Gel

Affiliations
  • 1Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
  • 2Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Seoul, Korea

Abstract

Purpose
Boron Neutron Capture Therapy (BNCT) is a treatment that injects boron into cancer, irradiates neutrons and kills only cancer cells, and neutron dose evaluation is a very important issue. The objective of this study is to produce polymer gels by mixing various materials to evaluate patient dose and incident neutron dose in BNCT, and to evaluate its properties for neutron dose evaluation.
Methods
This study used MC-50 cyclotron installed in our institution to evaluate neutron dose. The MC-50 cyclotron uses protons as a source, can irradiate the neutron with a beryllium target from proton, and accelerate up to 50 MeV. Polymer gels were prepared by mixing HPLC, Gelatin, Methacrylic acid (MAA), Hydroquinone (HQ) and Tetrackis hydozymethyl phosphonium chloride (THPC). Li2SO4, LiCl, and LIF were added to confirm neutron interaction. In addition, in order to confirm only the interaction with the neutrons, a polymer gel containing no neutron reaction material was prepared. The neutron doses were evaluated using a total of four polymer gels.In order to evaluate neutron doses separately by measuring the effects of neutrons and gamma rays separately, the gamma doses were evaluated using standard gamma rays (60-Co).
Results
The properties of the polymer gel showed linearity as the neutron doses were increased to 5, 10, 15 Gy. In addition, as a result of repeated experiments using the same sample, the neutron dose was reproducible within 5%.
Conclusions
The polymer gel developed in this study is expected to be used for various neutron experiments. In the future, various polymer gels will be used to investigate properties according to neutron dose rate and energy to study the polymer gel component ratio suitable for BNCT.

Keyword

BNCT; Neutron dosimetry; Polymer gel; MC-50 cyclotron
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