Lab Med Qual Assur.  2023 Dec;45(4):149-155. 10.15263/jlmqa.2023.45.4.149.

Performance Evaluation of the Beckman Coulter DxH 900 Automated Hematology Analyzer

• Yu S
• Lee JY
• You E
• Song SA
• Lee JN
• Jun KR

• KMID: 2549789
• DOI: http://doi.org/10.15263/jlmqa.2023.45.4.149

Abstract

Background
The Beckman Coulter DxH 900 hematology analyzer (Beckman Coulter Inc., USA) is based on the Coulter Principle and accurately counts and measures the size of cells by monitoring changes in the electrical resistance of cells in a conductive liquid. Monocyte distribution width (MDW) is a new parameter of the DxH 900 analyzer that assists in the early diagnosis of sepsis. We evaluated the analytical performance of the DxH 900 for all parameters, including MDW.
Methods
We evaluated the precision, linearity, and carryover-related performance of the DxH 900, and analyzed the correlation between the DxH 900 and XE-2100 (Sysmex Corp., Japan) analyzers for all parameters (except MDW).
Results
The DxH 900 demonstrated acceptable precision for measuring normal and abnormal high- and low-level quality controls. The MDW repeatability was good (coefficient of variation of 3.99%–6.68%). White blood cells, red blood cells, hemoglobin, and platelets exhibited excellent linearity at high and low ranges, and no carryover effect was seen. The results obtained from the DxH 900 and XE-2100 analyzers were highly correlated.
Conclusions
The parameters including MDW of the DxH 900 analyzer showed good analytical performance and reproducibility. The parameters correlated well with the existing model, XE-2100. Our study demonstrated that the DxH 900 is useful in routine laboratories.

Keyword

Hemoglobins; Monocyte distribution width; Performance evaluation; Automated hematology analyzer