Restor Dent Endod.  2022 Aug;47(3):e27. 10.5395/rde.2022.47.e27.

Association between cigarette smoking and the prevalence of postendodontic periapical pathology: a systematic review and meta-analysis

• Ríos-Osorio N
• Muñoz-Alvear HD
• Jiménez-Castellanos FA
• Quijano-Guauque S
• Jiménez-Peña O
• García-Perdomo HA
• Caviedes-Bucheli J

• KMID: 2548131
• DOI: http://doi.org/10.5395/rde.2022.47.e27

Abstract

Objectives
This systematic review and meta-analysis aimed to assess the association of cigarette smoking with the prevalence of post-endodontic apical periodontitis in humans.
Materials and Methods
We searched through PubMed/Medline, Web of Science, and Scopus from inception to December 2020. Risk of bias was performed by using the NewcastleOttawa Scale for cross-sectional, cohort, and case-control studies. We performed the statistical analysis in Review Manager 5.3 (RevMan 5.3).
Results
6 studies met the inclusion criteria for qualitative and quantitative synthesis. Statistical analysis of these studies suggests that there were no differences in the prevalence of post endodontic apical periodontitis (AP) when comparing non-smokers vs smoker subjects regarding patients (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.31–1.49; I2 = 58%) and teeth (OR, 1.71; 95% CI, 0.99–2.93; I2 = 72%).
Conclusions
Our findings suggest that there was no association between cigarette smoking and post-endodontic apical periodontitis, as we did not find statistical differences in the prevalence of post-endodontic AP when comparing non-smokers vs smoker subjects. Therefore, smoking should not be considered a risk factor associated with endodontic failure.

Keyword

Root canal treatment; Apical periodontitis; Cigarette smoking; Systematic review

Figure

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  Figure 1 Flowchart of included studies.

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  Figure 2 Forest plot of association between root canal treatment with apical periodontitis in smokers vs non-smokers subjects (analysis by patients).OR, odds ratio; CI, Confidence interval.

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  Figure 3 Forest plot of association between root canal treatment with apical periodontitis in smokers vs non-smokers subjects (analysis by teeth).OR, odds ratio; CI, Confidence interval.

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