J Dig Cancer Res.  2024 Dec;12(3):207-215. 10.52927/jdcr.2024.12.3.207.

Systematic Review and Meta-analysis in Digestive Cancer Research

• Gwon SH
• Son NH

• KMID: 2563745
• DOI: http://doi.org/10.52927/jdcr.2024.12.3.207

Abstract

This article highlights the role of meta-analysis as a statistical method for quantitatively summarizing existing research and reconciling conflicting findings. It discusses literature search methods for meta-analysis, the selection and interpretation of statistical models, and publication bias. Meta-analysis allows for the statistical consideration of homogeneity and heterogeneity among studies. Determining homogeneity and heterogeneity is crucial for selecting the appropriate meta-analysis model. Systematic reviews and meta-analyses provide a high level of evidence on treatment efficacy, especially when they include multicenter and multinational studies. In the case of well-researched disorders such as digestive cancer, meta-analysis can be useful in generalizing findings from existing papers, draw conclusions, and evaluate related medical technologies. Furthermore, these findings can be used to propose or enhance standards of care.

Keyword

Models, statistical; Meta-analysis; Publication bias; Systematic review