J Korean Neurol Assoc.
2023 Nov;41(4):268-273. 10.17340/jkna.2023.0037.
Digital Biomarkers for Alzheimer’s Disease
- Affiliations
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- 1Department of Neurology, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea
- KMID: 2547614
- DOI: http://doi.org/10.17340/jkna.2023.0037
Abstract
- There is a growing interest in developing new biomarkers using digital devices. The primary purpose of digital biomarkers is to obtain features based on multi-dimensional data such as multiple data sources from various digital devices and time-series data reflecting temporal changes. Therefore, digital biomarkers can be used to measure the behavioral patterns of individuals in their daily lives in contrast to traditional biomarkers that reflect specific time points in clinical or laboratory settings. However, there are still several limitations including validation and interpretation. This article reviews the potential of digital biomarkers, explores previous studies on digital phenotypes related to Alzheimer’s disease, and discusses the future challenges of implementing digital biomarkers in the medical field.
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