Allergy Asthma Respir Dis.  2023 Oct;11(4):211-215. 10.4168/aard.2023.11.4.211.

Whole lung lavage with granulocyte macrophage colony-stimulating factor inhalation in children with pulmonary alveolar proteinosis: A case report

• Kim S
• Park MJ
• Song KB
• Choi EJ
• Paek EY
• Lee D
• Hong SJ

• KMID: 2547453
• DOI: http://doi.org/10.4168/aard.2023.11.4.211

Abstract

Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by hypoxemic respiratory failure due to the accumulation of lipoproteinaceous material in alveolar macrophages and alveoli. It has been reported that granulocyte macrophage colony-stimulating factor (GM-CSF) inhalation or whole lung lavage significantly improves the disease state. We present a case of 17-year-old female diagnosed with PAP and treated with both GM-CSF inhalation and whole lung lavage. Her symptoms, imaging findings, and pulmonary function tests improved after these treatments. Therefore, combined treatments of whole lung lavage and subsequent GM-CSF inhalation should be considered a treatment option for children and adolescents.

Keyword

Pulmonary alveolar proteinosis; Whole lung lavage; Granulocyte macrophage colony-stimulating factor inhalation; Child