Korean J Transplant.  2023 Sep;37(3):216-219. 10.4285/kjt.23.0035.

Graft lymphoma in a kidney transplant recipient: a case report

• Yeom JH
• Kim W
• Kang KP
• Kim H
• Yu HC
• Hwang HP
• Chung BH
• Jang KY
• Lee S

• KMID: 2546502
• DOI: http://doi.org/10.4285/kjt.23.0035

Keyword

Kidney transplantation; Lymphoproliferative disorders; Epstein-Barr virus; Case reports

Figure

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  Fig. 1 (A) Enhanced computed tomography showed graft swelling and multiple low-attenuated areas with calyceal dilatation in the transplanted kidney. Internal calcification and peripheral fat stranding were also confirmed. (B) A similar finding was observed in the coronary section. (C) A low-attenuating infiltrative lesion was found around the ureter of the transplanted kidney, but there was no hydronephrosis.

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  Fig. 2 (A) Atypical lymphoid cells infiltrate diffusely between sclerotic glomerulus (asterisk) and atrophic renal tubules (arrows). (B) The tumor cells have large nuclei with conspicuous nucleoli. (C) The tumor cells are positive for CD20 (D) but negative for CD3. (E) The tumor cells are positive for EBER in situ hybridization and (F) show a high Ki67-positive proliferation index. Original magnification: (A) ×100, (B-F) ×400. (A, B) Hematoxyline and eosin stain, (C–F) Immunohistochemical stain.

Reference

1. Opelz G, Döhler B. 2004; Lymphomas after solid organ transplantation: a collaborative transplant study report. Am J Transplant. 4:222–30. DOI: 10.1046/j.1600-6143.2003.00325.x. PMID: 14974943.

2. Francis A, Johnson DW, Teixeira-Pinto A, Craig JC, Wong G. 2018; Incidence and predictors of post-transplant lymphoproliferative disease after kidney transplantation during adulthood and childhood: a registry study. Nephrol Dial Transplant. 33:881–9. DOI: 10.1093/ndt/gfx356. PMID: 29342279.

3. Park H, Kim JS, Kong JH, Kim SH, Park SW, Song SH, et al. 2016; Post-transplant lymphoproliferative disorder in transplanted kidney causing urinary tract obstruction. J Korean Soc Transplant. 30:44–9. DOI: 10.4285/jkstn.2016.30.1.44.

4. Kim B, Kang M, Kim Y, Lee HS, Kim B, Lee JJ, et al. 2021; De novo cancer incidence after kidney transplantation in South Korea from 2002 to 2017. J Clin Med. 10:3530. DOI: 10.3390/jcm10163530. PMID: 34441826. PMCID: PMC8396914.

5. San-Juan R, Comoli P, Caillard S, Moulin B, Hirsch HH, Meylan P. 2014; Epstein-Barr virus-related post-transplant lymphoproliferative disorder in solid organ transplant recipients. Clin Microbiol Infect. 20 Suppl 7:109–18. DOI: 10.1111/1469-0691.12534. PMID: 24475976.

6. Yabu JM, Winkelmayer WC. 2011; Posttransplantation anemia: mechanisms and management. Clin J Am Soc Nephrol. 6:1794–801. DOI: 10.2215/CJN.01190211. PMID: 21734096.