Blood Res.  2023 Sep;58(3):157-161. 10.5045/br.2023.2023132.

A challenging diagnosis of hepatosplenic T cell lymphoma in a 10-year-old child

• Ali SK
• Alomar SA
• Salih HM
• Yaseen NS

• KMID: 2546321
• DOI: http://doi.org/10.5045/br.2023.2023132

Figure

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  Fig. 1 Axial and coronal CT scan of the abdomen showing hepato-splenomegaly.

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  Fig. 2 Morphological, histological, and immunostaining of HSTCL: BM aspirate smear showing (A, B) neoplastic cells with blastoid morphology and (C, D) lymphoma cells arranged in clusters. BM biopsy section: (E) hematoxylin and eosin staining showing sinusoidal and subtle interstitial marrow infiltration, highlighted by (F) CD3 IHC staining, (G) cells are negative for β TCR stain and positive for (H) Gamma IHC stain (A-D: Diff-Quik, oil emersion; E and F: ×400 magnification; G and H: ×200 magnification).

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  Fig. 3 Flowcytometry of BM aspirate revealed 48% abnormal T-cells in the lymphocytes region (green population) of the following immunophenotype: bright CD45 and sCD3 with dim CD7 and CD56, negative CD5, CD4, CD8, and CD34 expression.

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