Korean J Hematol.
2002 May;37(2):134-137.
A Case of Bone Marrow Involvement of Hepatosplenic gamma delta-Cell Lymphoma
- Affiliations
-
- 1Department of Clinical Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea. sunnyhk@smc.samsung.co.kr
- 2Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 3Department of Diagnostic Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract
- Hepatosplenic gamma delta-cell lymphoma is a rare histologic type of peripheral T-cell lymphomas, clinically characterized by predominant involvement of liver and spleen, no or little adenopathy, and an often aggressive course. We report a case of bone marrow involvement of hepatosplenicgamma delta-cell lymphoma in a 21- year-old woman who presented with fever, anemia, thrombocytopenia, and hepatosplenomegaly. A lymphoma was found subsequently by bone marrow biopsy and computed tomography scan of the abdomen and pelvis. Immunologic characterization of lymphoma cells in bone marrow revealed positivity for CD2, CD3, and CD16/56, and negativity for CD4, CD5, CD7, CD8, CD34, and terminal deoxynucleotidyl transferase (TdT). Conventional cytogenetic studies revealed the presence of isochromosome 7q. Using the PCR-SSCP technique, monoclonal gene rearrangement of the T-cell receptor gamma chain was demonstrated. Thus, we could make a confirmatory diagnosis as hepatosplenic gamma delta-cell lymphoma.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of Successful Allogeneic Stem Cell Transplantation for Chemotherapy-refractory Hepatosplenic gamma delta-T Cell Lymphoma
- A Case of Hepatosplenic T-cell Lymphoma Diagnosed by Bone Marrow Examination
- An Adolescent Case of Hepatosplenic T-cell Lymphoma
- Sinusoidal infiltration of hepatosplenic lymphoma in liver and bone marrow
- A Case of Hepatosplenic T-cell Lymphoma with Colonic Involvement
