Korean J Biol Psychiatry.
2023 Apr;30(1):17-23. 10.22857/kjbp.2023.30.1.003.
Chronic Reserpine Administration for Depression Modeling in Zebrafish
- Affiliations
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- 1Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea
- 2Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
- 3Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea
- 4Zebrafish Translational Medical Research Center, Korea University, Ansan, Korea
- KMID: 2541992
- DOI: http://doi.org/10.22857/kjbp.2023.30.1.003
Abstract
Objectives
This study aims to develop valid experimental models for depression through chronic reserpine exposure to zebrafish (Danio rerio).
Methods
The effect of chronic reserpine on zebrafish behavior in the novel tank was examined. Changes of gene expression on telencephalon were also investigated.
Results
Chronic reserpine (40 mg/L, 7 days) induced overt behavioral effects, but markedly reduced activity, resembling motor retardation in depression. In telencephalon of zebrafish, gene expression associated with monoamine oxidase and norepinephrine transporter was decreased. Expression of serotonin transporter gene was increased.
Conclusions
Our results show that the pharmacological model of depression in zebrafish can induce not only behavioral changes, but also monoamine changes in the homology of human mood regulation centers.
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