- Chronic Reserpine Administration for Depression Modeling in Zebrafish
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Kim S, Han C, Ko YH, Kim YK, Yoon HK, Lee J, Kim S, Lee C, Shin C
- KMID: 2541992
- Korean J Biol Psychiatry.
- 2023 Apr;30(1):17-23.
- doi: 10.22857/kjbp.2023.30.1.003
Objectives This study aims to develop valid experimental models for depression through chronic reserpine exposure to zebrafish (Danio rerio). Methods The effect of chronic reserpine on zebrafish behavior in the novel tank was... -
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- Development of a Zebrafish Larvae Model for Diabetic Heart Failure With Reduced Ejection Fraction
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Kim I, Seok SH, Lee HY
- KMID: 2538103
- Korean Circ J.
- 2023 Jan;53(1):34-46.
- doi: 10.4070/kcj.2022.0210
Background and Objectives: Diabetes mellitus (DM)-associated heart failure (HF) causes high morbidity and mortality. In this study, we established a zebrafish larvae model for in vivo research on diabetic HF. Methods:... -
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- Treatment with a 1,064 nm low-fluence Q-switched Nd:YAG laser in multipulse mode can delay repigmentation in a zebrafish model of laser toning in Republic of Korea: a before and after study
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Jung J, Kim H, Park J, Hwang JK
- KMID: 2537595
- Med Lasers.
- 2022 Dec;11(4):219-228.
- doi: 10.25289/ML.22.039
Background and Objectives: A novel multipulse mode has been developed for the Q-switched 1,064 nm Nd:YAG laser (Q-NYL) which may help prevent rebound pigmentation after laser toning for melasma. The... -
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- Transgenic fluorescent zebrafish lines that have revolutionized biomedical research
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Choe CP, Choi SY, Kee Y, Kim MJ, Kim SH, Lee Y, Park HC, Ro H
- KMID: 2521032
- Lab Anim Res.
- 2021 Sep;37(3):156-184.
- doi: 10.1186/s42826-021-00103-2
Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish... -
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- Zebrafish Vascular Development: General and Tissue-Specific Regulation
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Nakajima H, Chiba A, Fukumoto M, Morooka N, Mochizuki N
- KMID: 2516882
- J Lipid Atheroscler.
- 2021 May;10(2):145-159.
- doi: 10.12997/jla.2021.10.2.145
Circulation is required for the delivery of oxygen and nutrition to tissues and organs, as well as waste collection. Therefore, the heart and vessels develop first during embryogenesis. The circulatory system... -
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- Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases
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Ka J, Jin SW
- KMID: 2512930
- J Lipid Atheroscler.
- 2021 Jan;10(1):42-56.
- doi: 10.12997/jla.2021.10.1.42
Dyslipidemia related diseases such as hyperlipidemia and atherosclerosis are the leading cause of death in humans. While cellular and molecular basis on the pathophysiology of dyslipidemia has been extensively investigated... -
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- Notch Signaling Controls Oligodendrocyte Regeneration in the Injured Telencephalon of Adult Zebrafish
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Kim HK, Lee Dw, Kim E, Jeong I, Kim S, Kim BJ, Park HC
- KMID: 2510504
- Exp Neurobiol.
- 2020 Dec;29(6):417-424.
- doi: 10.5607/en20050
The myelination of axons in the vertebrate nervous system through oligodendrocytes promotes efficient axonal conduction, which is required for the normal function of neurons. The central nervous system (CNS) can... -
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- Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure
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Quan H, Oh GC, Seok SH, Lee HY
- KMID: 2508136
- Korean J Intern Med.
- 2020 Nov;35(6):1400-1410.
- doi: 10.3904/kjim.2019.038
Background/Aims: Angiotensin II in the failing heart initially helps to maintain cardiac output and blood pressure, but ultimately accelerates its deterioration. In this study, we established a model of arrhythmia-induced... -
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- Highlights on selected microscopy techniques to study zebrafish developmental biology
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Abu-Siniyeh A, Al-Zyoud W
- KMID: 2506035
- Lab Anim Res.
- 2020 Jun;36(2):88-97.
- doi: 10.1186/s42826-020-00044-2
Bio-imaging is a tedious task when it concerns exploring cell functions, developmental mechanisms, and other vital processes in vivo. Single-cell resolution is challenging due to different issues such as sample... -
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- Evaluation of the Toxicity of Sugammadex in Zebrafish Larvae
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Kim WY, Kim YH, Lee JY, Kim JH, Min TJ
- KMID: 2471204
- J Korean Med Sci.
- 2020 Mar;35(9):e51.
- doi: 10.3346/jkms.2020.35.e51
BACKGROUND: Sugammadex is a new neuromuscular blockade reversal agent. Recently, it has been used in patients under general anesthesia. However, sugammadex could be toxic to fetuses and pediatric patients under... -
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- Induction of cell deathin early developmental phase of zebrafish treated with diethylnitrosamine
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Kang JS
- KMID: 2463591
- J Biomed Transl Res.
- 2019 Sep;20(3):53-57.
- doi: 10.12729/jbtr.2019.20.3.053
The purpose of this study was to investigate diethylnitrosamine (DEN)-induced liver damage in zebrafish. Zebrafish larvae were divided into five groups after seventy-two hours fertilization: group 1 (G1) as control,... -
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- AcuD Gene Knockout Attenuates the Virulence of Talaromyces marneffei in a Zebrafish Model
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Feng J, Chen Z, He L, Xiao X, Chen C, Chu J, Mylonakis , Xi L
- KMID: 2455701
- Mycobiology.
- 2019 Jun;47(2):207-216.
- doi: 10.1080/12298093.2019.1620975
Talaromyces marneffei is the only dimorphic species in its genus and causes a fatal systemic mycosis named talaromycosis. Our previous study indicated that knockdown of AcuD gene (encodes isocitrate lyase... -
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- Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner
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Kim M, Gu GJ, Koh YS, Lee SH, Na YR, Seok SH, Lim KM
- KMID: 2427514
- Biomol Ther.
- 2018 Nov;26(6):599-607.
- doi: 10.4062/biomolther.2017.225
Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical... -
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- Impact of Nicotine Exposure on Hair Cell Toxicity and Embryotoxicity During Zebrafish Development
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Yoo MH, Rah YC, Park S, Koun S, Im GJ, Chae SW, Jung HH, Choi J
- KMID: 2412668
- Clin Exp Otorhinolaryngol.
- 2018 Jun;11(2):109-117.
- doi: 10.21053/ceo.2017.00857
OBJECTIVES: Nicotine has various adverse effects including negative impacts associated with maternal exposure. In the current study, we examined nicotine-induced damage of hair cells and embryotoxicity during zebrafish development. METHODS: Zebrafish... -
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- Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish
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Jeong JW, Cha HJ, Han MH, Hwang SJ, Lee DS, Yoo JS, Choi IW, Kim S, Kim HS, Kim GY, Hong SH, Park C, Lee HJ, Choi YH
- KMID: 2429054
- Biomol Ther.
- 2018 Mar;26(2):146-156.
- doi: 10.4062/biomolther.2016.272
Spermidine is a naturally occurring polyamine compound that has recently emerged with anti-aging properties and suppresses inflammation and oxidation. However, its mechanisms of action on anti-inflammatory and antioxidant effects have... -
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- microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish
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Kim CW, Han JH, Wu L, Choi JY
- KMID: 2418861
- Yonsei Med J.
- 2018 Jan;59(1):141-147.
- doi: 10.3349/ymj.2018.59.1.141
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the... -
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- Phenolic Compounds from the Leaves of Homonoia riparia and their Inhibitory Effects on Advanced Glycation End Product Formation
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Lee IS, Jung SH, Kim CS, Kim JS
- KMID: 2401580
- Nat Prod Sci.
- 2017 Dec;23(4):274-280.
- doi: 10.20307/nps.2017.23.4.274
In a search for novel treatments for diabetic complications from natural resources, we found that the ethyl acetate-soluble fraction from the 80% ethanol extract of the leaves of Homonoia riparia... -
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- Saprolegnia parasitica Isolated from Rainbow Trout in Korea: Characterization, Anti-Saprolegnia Activity and Host Pathogen Interaction in Zebrafish Disease Model
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Shin S, Kulatunga , Dananjaya , Nikapitiya C, Lee J, De Zoysa M
- KMID: 2401059
- Mycobiology.
- 2017 Dec;45(4):297-311.
- doi: 10.5941/MYCO.2017.45.4.297
Saprolegniasis is one of the most devastating oomycete diseases in freshwater fish which is caused by species in the genus Saprolegnia including Saprolegnia parasitica. In this study, we isolated the... -
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- Zebrafish Larvae Model of Dilated Cardiomyopathy Induced by Terfenadine
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Gu G, Na Y, Chung H, Seok SH, Lee HY
- KMID: 2396489
- Korean Circ J.
- 2017 Nov;47(6):960-969.
- doi: 10.4070/kcj.2017.0080
BACKGROUND AND OBJECTIVES: Dilated cardiomyopathy can be the end-stage of severe cardiac disorders and directly affects the cardiac muscle, inducing cardiomegaly and heart failure (HF). Although a wide variety of... -
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- Morphologic Changes of Zebrafish Melanophore after Intense Pulsed Light and Q-Switched Nd:YAG Laser Irradiation
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Ryu HJ, Lee JM, Jang HW, Park HC, Rhyu IJ, Kim IH
- KMID: 2368121
- Ann Dermatol.
- 2016 Dec;28(6):711-717.
- doi: 10.5021/ad.2016.28.6.711
BACKGROUND: Recently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma. OBJECTIVE: To observe the morphologic changes in the melanophore in adult zebrafish... -
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