Int J Gastrointest Interv.  2023 Apr;12(2):69-74. 10.18528/ijgii220012.

The prognostic value of tumor budding in gastric adenocarcinomas: A cross-sectional study

• Baydas T
• Coban G
• Besiroglu M
• Simsek M
• Shbair AT
• Topcu A
• Yasin AI
• Seker M
• Turk HM

• KMID: 2541769
• DOI: http://doi.org/10.18528/ijgii220012

Abstract

Background
Tumor budding is a negative prognostic factor for many solid malignancies. We investigated the relationship between patients’ clinicopathological characteristics and tumor budding, as well as the effect of budding level on prognosis.
Methods
In this retrospective, cross-sectional, and descriptive study at a tertiary university hospital, 104 patients with gastric adenocarcinoma were divided into two groups according to whether they had a high (≥ 10 buds) or low (< 10 buds) level of budding. The patients were retrospectively evaluated.
Results
Sixty-two patients had a low level of budding and 42 had a high level of budding. The mean time from the first diagnosis to the last followup was significantly longer (P < 0.05) in the low-budding group (27 months) than in the high-budding group (17 months). As the T stage, N stage, grade, and size of the tumor increased, the proportion of patients with high budding was found to be significantly higher (P < 0.05). High tumor budding, an age of 60 or over at diagnosis, a low body mass index, high N stage, presence of lymphovascular invasion, and recurrence were associated with overall survival.
Conclusion
Our study supports that budding is a negative prognostic factor in gastric cancer.

Keyword

Adenocarcinoma; Prognosis; Stomach neoplasms