Ann Surg Treat Res.  2023 Feb;104(2):101-108. 10.4174/astr.2023.104.2.101.

Clinical outcomes of gastric cancer surgery after liver transplantation

• Kim S
• Lee HJ
• Alzahrani F
• Kim J
• Kim SH
• Kim S
• Cho YS
• Park JH
• Lee JM
• Kong SH
• Park DJ
• Suh KS
• Yang HK

• KMID: 2539224
• DOI: http://doi.org/10.4174/astr.2023.104.2.101

Abstract

Purpose
De novo malignancy is common after liver transplantation (LT); however, there are limited reports on the clinical outcomes of gastric cancer surgery after LT. Our study aimed to investigate the feasibility and safety of gastric cancer surgery after LT.
Methods
Seventeen patients underwent gastric cancer surgery after LT at a single institution between January 2013 and June 2021. We retrospectively collected data on surgical complications, survival, and recurrence status of these cases.
Results
Fifteen patients (88.2%) underwent curative gastrectomy, with 10 open distal (66.7%) and 5 laparoscopic distal (33.3%) gastrectomies. Surgical and severe complication rates were 3 of 15 (20.0%) and 1 of 15 (6.7%), respectively. There were no significant differences between laparoscopic (33.3%) and open surgery (66.7%) in terms of operation time and complication rate. No surgery-related mortalities occurred. Immunosuppressants could be maintained without difficulty, and no suspicious acute rejection was identified during the perioperative period. There was 1 recurrence after curative surgery (recurrence rate, 6.7%), and the 5-year cancer-specific survival rate after curative surgery was 93.3%.
Conclusion
Laparoscopic gastrectomy can be safely done even after LT in terms of postoperative complications and graft safety.

Keyword

Gastrectomy; Liver transplantation; Stomach neoplasms

Figure

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  Fig. 1 (A) Adhesion to the abdomen wall. (B) Adhesion around the liver.

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  Fig. 2 Perioperative AST (A) and ALT (B) levels. OPD, outpatient department.

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