Immune Netw.  2022 Dec;22(6):e47. 10.4110/in.2022.22.e47.

Increased B Cell Understanding Puts Improved Vaccine Platforms Just Over the Horizon

• Notario GR
• Kwak K

• KMID: 2538489
• DOI: http://doi.org/10.4110/in.2022.22.e47

Abstract

In the face of an endlessly expanding repertoire of Ags, vaccines are constantly being tested, each more effective than the last. As viruses and other pathogens evolve to become more infectious, the need for efficient and effective vaccines grows daily, which is especially obvious in an era that is still attempting to remove itself from the clutches of the severe acute respiratory syndrome coronavirus 2, the cause of coronavirus pandemic. To continue evolving alongside these pathogens, it is proving increasingly essential to consider one of the main effector cells of the immune system. As one of the chief orchestrators of the humoral immune response, the B cell and other lymphocytes are essential to not only achieving immunity, but also maintaining it, which is the vital objective of every vaccine.

Keyword

Vaccine; Immunology; B cell; Rational vaccine design