J Yeungnam Med Sci.  2022 Apr;39(2):89-97. 10.12701/jyms.2021.01669.

Coronavirus disease 2019 (COVID-19) vaccine platforms: how novel platforms can prepare us for future pandemics: a narrative review

• Lee JK
• Shin OS

• KMID: 2529266
• DOI: http://doi.org/10.12701/jyms.2021.01669

Abstract

More than 2 years after the explosion of the coronavirus disease 2019 (COVID-19) pandemic, extensive efforts have been made to develop safe and efficacious vaccines against infections with severe acute respiratory syndrome coronavirus 2. The pandemic has opened a new era of vaccine development based on next-generation platforms, including messenger RNA (mRNA)-based technologies, and paved the way for the future of mRNA-based therapeutics to provide protection against a wide range of infectious diseases. Multiple vaccines have been developed at an unprecedented pace to protect against COVID-19 worldwide. However, important knowledge gaps remain to be addressed, especially in terms of how vaccines induce immunogenicity and efficacy in those who are elderly. Here, we discuss the various vaccine platforms that have been utilized to combat COVID-19 and emphasize how these platforms can be a powerful tool to react quickly to future pandemics.

Keyword

COVID-19; Pandemics; Platforms; Vaccines

Figure

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  Fig. 1. Different strategies to develop coronavirus disease 2019 (COVID-19) vaccines. Classical and next-generation platform-based vaccines that have been developed as a countermeasure to the COVID-19 pandemic are shown. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; mRNA, messenger RNA.

Reference

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