Oral Biol Res.  2022 Dec;46(4):183-188. 10.21851/obr.46.04.202212.183.

The etiology and possible molecular mechanisms underlying calcium channel blocker-induced gingival enlargement: a narrative review

• Lee S
• You HK

• KMID: 2537680
• DOI: http://doi.org/10.21851/obr.46.04.202212.183

Abstract

Gingival enlargement, defined as the abnormal proliferation of gingival tissue, can be caused by exposure to poor oral hygiene, periodontal diseases, or systemic drugs such as antihypertensive, immunosuppressive, and anticonvulsant agents. Although numerous clinical studies have examined drug-induced gingival enlargement, there is limited evidence on the molecular mechanisms underlying this disease. Therefore, the current study aims to summarize the available literature on the effects of systemic drugs such as antihypertensive agents and calcium channel blockers used for the treatment of cardiac diseases on gingival enlargement expression, and to discuss possible molecular mechanisms underlying drug-induced gingival enlargement.

Keyword

Antihypertensive agents; Calcium channel blockers; Drug-induced gingival enlargement