Immune Netw.
2022 Feb;22(1):e12. 10.4110/in.2022.22.e12.
Recent Advances in Allergen-Specific Immunotherapy in Humans: A Systematic Review
- Affiliations
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- 1Division of Pulmonology and Allergy, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
- 2Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
- 3Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- KMID: 2536230
- DOI: http://doi.org/10.4110/in.2022.22.e12
Abstract
- Allergen-specific immunotherapy (AIT) is presumed to modulate the natural course of allergic disease by inducing immune tolerance. However, conventional AITs, such as subcutaneous immunotherapy and sublingual immunotherapy, require long treatment durations and often provoke local or systemic hypersensitivity reactions. Therefore, only <5% of allergy patients receive AIT as second-line therapy. Novel administration routes, such as intralymphatic, intradermal and epicutaneous immunotherapies, and synthetic recombinant allergen preparations have been evaluated to overcome these limitations. We will review the updated views of diverse AIT methods, and discuss the limitations and opportunities of the AITs for the treatment of allergic diseases in humans.
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