Clin Exp Pediatr.
2024 Aug;67(8):386-394. 10.3345/cep.2023.01004.
Recent advances in food allergen immunotherapy
- Affiliations
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- 1Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea
- 2Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA
- KMID: 2558226
- DOI: http://doi.org/10.3345/cep.2023.01004
Abstract
- Food allergies can pose significant risks and profoundly impact the quality of life of children and their families, making them a major public health concern. Allergen avoidance has been the traditional mainstay of treatment; however, recent research has focused on various approaches to food allergen immunotherapy. This review summarizes the recent advancements in oral, sublingual, and epicutaneous immunotherapies, highlighting their respective advantages and disadvantages. The ultimate goal of food allergen immunotherapy is to maximize efficacy while minimizing risks, leading to the exploration of strategies such as low-dose immunotherapy and the use of biologics. When selecting candidates for immunotherapy among patients with food allergies, factors such as allergen characteristics, the likelihood of natural resolution, age, symptom severity, and impact on quality of life require consideration, and an individualized approach should be adopted to determine the most suitable treatment method.
