J Pharmacoepidemiol Risk Manage.
2022 Sep;14(2):169-172. 10.56142/jperm.22.0016.
A Case Report of Guaifenesin-Induced Anaphylaxis
- Affiliations
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- 1Drug Safety Center Seoul National University Hospital, Seoul, Korea
- 2Seoul National University Hospital Regional Pharmacovigilance Center, Seoul, Korea
- 3Department of Pharmacy, Seoul National University Hospital, Seoul, Korea
- 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2534689
- DOI: http://doi.org/10.56142/jperm.22.0016
Abstract
- Guaifenesin (glyceryl guaiacolate) is widely used as an expectorant by reducing the viscosity and increasing the volume of bronchial secretions. It is usually used as a combination complex with acetaminophen, ephedrine, chlorpheniramine or dextromethorphan, and its known side effects are mostly mild including nausea, anorexia, abdominal discomfort, and somnolence. We experienced a case of a healthy woman, who encountered anaphylactic reaction to medicines including guaifenesin. Since concomitant drugs were ruled out with drug provocation test and skin test, we concluded guaifenesin as the culprit drug. Although guaifenesin, commonly used over-the-counter drug, is known to have a good tolerability and safety profile, patients as well as medical professionals should always be aware of the possibility of anaphylaxis.
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