J Pharmacoepidemiol Risk Manage.
2021 Mar;13(1):24-29. 10.56142/2021.13.1.24.
Improving the Prescription System to Prevent Adverse Drug Reactions
- Affiliations
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- 1Drug Safety Monitoring Center, Seoul National University Hospital, Seoul, Korea
- 2Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, Korea
- 3Department of Pharmacy, Seoul National University Hospital, Seoul, Korea
- 4Office of Hospital Information, Seoul National University Hospital, Seoul, Korea
- 5Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
- 6Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea
- KMID: 2534645
- DOI: http://doi.org/10.56142/2021.13.1.24
Abstract
Objective
Many medical institutions provide warnings when physicians prescribe medication with a history of adverse reaction to prevent adverse drug reaction. If the range of warning is too narrow, it cannot prevent adverse drug reactions due to a similar structure and component. However, if the range is too wide it provides too many warnings resulting in alert fatigue. In our study, we upgraded the algorithm for adverse drug reaction warning to lower the overall frequency of alert warning but improve the clinical significance of alerts.
Methods
The authors upgraded the alert algorithm to include information about the potential for cross-reactivity, past adverse drug reaction type, severity, and causality. To verify the effect of the upgraded system, we compared the frequency of alerts of six months before and after the system upgrade, a satisfaction of physicians using the upgraded prescription system, and recurrence of drug allergy.
Results
After six months of upgraded prescription system, the number of alerts decreased significantly from 10,474 cases per month to 1,060 cases per month (p ＜ 0.05). The recurrence of drug allergy decreased by 53%, from 57 cases to 27 cases per 6 months. Survey results show that physician satisfaction improved from 3.48 points to 4.15 points and improvement in patient care improved from 3.80 points to 4.33 points significantly (p ＜ 0.05).
Conclusion
By reducing the number of clinically less important warnings, the upgraded prescription system can raise the interest in clinically significant adverse reactions and it can be effective in preventing recurrence of adverse drug reactions.
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