J Korean Soc Laryngol Phoniatr Logoped.  2022 Aug;33(2):110-114. 10.22469/jkslp.2022.33.2.110.

A Case of IgG4-Related Pseudotumor in Larynx

• Lee MH
• Hong JP
• Kim TH
• Jin SM

• KMID: 2533071
• DOI: http://doi.org/10.22469/jkslp.2022.33.2.110

Abstract

IgG4-related disease is a fibroinflammatory condition by infiltration of IgG4-positive plasma cells that often presents as a tumorous lesion. This disease can affect nearly every organ system. After the pancreas, the head and neck region is second most common site for presentation of IgG4- related disease such as Mikulicz’s disease, Küttner tumor. The involvement of IgG4-related disease in laryngeal lesions is extremely rare. We have experienced a case of IgG4-related disease with pseudotumor formation in the larynx that is suggestive of malignancy in radiologic findings. But the pathology findings was finally confirmed as IgG4-related disease. Oral treatment with prednisolone was initiated, and the edematous mass reduced in size without permanent functional impairment of vocal fold mobility. We report our experience with a literature review.

Keyword

Immunoglobulin G4-related disease; Larynx; Vocal cords; 면역글로불린 G4 연관 질환; 후두; 성대