Investig Magn Reson Imaging.  2024 Mar;28(1):55-60. 10.13104/imri.2023.0034.

MRI Findings for IgG4-Related Disease Involving the Liver and Gallbladder

• Jeong J
• Oh Hs

• KMID: 2554476
• DOI: http://doi.org/10.13104/imri.2023.0034

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition characterized by the infiltration of IgG4-positive plasma cells, increased serum IgG4 levels, and the development of mass-forming lesions. Involvement of the liver or gallbladder in IgG4-RD is uncommon. In this study, we report the magnetic resonance imaging findings of a hepatic inflammatory pseudotumor (IPT) and sclerosing cholecystitis in a 64-year-old male patient with IgG4-RD. IgG4-related hepatic IPT demonstrated intermediate signal intensity (SI) on T2-weighted images (T2WI), whereas no significant enhancement was observed in a T1-weighted dynamic study. Additionally, diffusion restrictions were not exhibited. IgG4-related sclerosing cholecystitis presented as a mass-forming lesion. It exhibited a low SI on T2WI, demonstrated prolonged enhancement during the arterial, portal venous, and transitional phases of T1-weighted dynamic studies, and did not exhibit prominent diffusion restriction.

Keyword

IgG4-related disease; Inflammatory pseudotumor; Sclerosing cholecystitis; Magnetic resonance imaging