Clin Psychopharmacol Neurosci.
2022 Aug;20(3):573-577. 10.9758/cpn.2022.20.3.573.
The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea
- Affiliations
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- 1Department of Research Planning, National Center for Mental Health, Seoul, Korea
- 2Mental Health Research Institute, National Center for Mental Health, Seoul, Korea
- KMID: 2532825
- DOI: http://doi.org/10.9758/cpn.2022.20.3.573
Abstract
Objective
To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizophrenia.
Methods
We analyzed data from the Korean National Health Insurance System−National Sample Cohort covering the 2002−2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high).
Results
Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia.
Conclusion
Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage.
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