Clin Psychopharmacol Neurosci.
2022 Aug;20(3):491-497. 10.9758/cpn.2022.20.3.491.
Adherence to Antipsychotic Drugs by Medication Possession Ratio for Schizophrenia and Similar Psychotic Disorders in the Republic of Korea: A Retrospective Cohort Study
- Affiliations
-
- 1Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- 2Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- 3Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
- 4Public Healthcare Center, Seoul National University Hospital, Seoul, Korea
- 5Department of Health Policy and Management, Seoul National University College of Medicine, Seoul, Korea
- 6HIRA Research Institute, Health Insurance Review and Assessment Service, Wonju, Korea
- 7Institue of Public Health and Medical Service, Seoul National University Hospital, Seoul, Korea
- 8Department of Psychiatry, Seoul National University Hospital, Seoul, Korea
- KMID: 2532811
- DOI: http://doi.org/10.9758/cpn.2022.20.3.491
Abstract
Objective
Pharmacotherapy is considered as an essential element in the treatment of psychotic disorders including schizophrenia. Discontinuation of antipsychotic drugs increases medical use and economic burden. Therefore, maintenance of medication is essential to reduce the social burden caused by schizophrenia and schizophrenia similar psychosis (SSP), and hence, it is important to investigate the rate at which pharmacotherapy is maintained. Therefore, this study aimed to examine the current status of drug compliance using national health insurance data.
Methods
This was a retrospective cohort study, which analyzed data from the nationwide insurance claims database. A total of 343,134 patients who were newly diagnosed with schizophrenia and SSP during 2011−2015. The adherence to antipsychotic drugs was assessed by medication possession ratio (MPR) and the risk factors of poor adherence were defined as MPR ＜ 40%.
Results
The average of the MPRs was 45.8%, and the proportion of patients with less than 40% of MPR was 50.8%. It was found that female patients, the experience of “general hospital outpatient,” “psychiatric hospital admission,” “general hospital admission,” and patients receiving “health insurance” showed high risk of having statistically significant low MPR (＜ 40%).
Conclusion
In this study, the drug adherence of schizophrenia and SSP patients currently under treatment, as estimated by MPR, was very low. However, it was also found that the MPR was high among patients receiving medical aid, with less medical expenses. Thus, it is possible to consider an institutional mechanism in which schizophrenia and SSP patients can be treated with less economic burden.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Development History of Antipsychotic Drugs
- One-Year Clinical Outcomes After Diagnosis According to Early Medication Adherence in First-Episode Schizophrenia: A Nationwide, Health Insurance Data-Based Retrospective Cohort Study
- Second-Generation Antipsychotic Discontinuation in First Episode Psychosis: An Updated Review
- Clinical Characteristics, Drug Adherence to Antipsychotics and Medical Use Trends in Patients First Diagnosed with Psychotic Disorder: A Preliminary Study
- The Drug Adherence and Treatment Effect of the Paliperidone Long Acting Injection
