Korean J Fam Pract.  2022 Apr;12(2):110-115. 10.21215/kjfp.2022.12.2.110.

Investigation of the Effect of Ultraviolet Light-Emitting Diodes Exposure Conditions on Serum Levels of 25-Hydroxyvitamin D in Female Adults with Vitamin D Insufficiency

  • 1Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea


To date, no research has been published on the effects of light-emitting diode (LED) devices emitting ultraviolet B (UVB) on serum 25-hydroxyvitamin D [25(OH)D] levels in humans. The objective of this study was to explore the efficacy and safety of UV-LED exposure by examining its effect on serum 25(OH)D levels in female adults with vitamin D insufficiency.
Among 13 female adults who visited the outpatient clinic of the Department of Family Medicine, Kangbuk Samsung Hospital, from June to July 2021, 9 female adults were included in the final analysis. Vitamin D insufficiency is defined as a serum 25(OH)D level of <30 ng/mL. The participants received UV-LED exposure three times per week for six weeks. Adverse reactions were assessed every two weeks after the first UV-LED exposure. The primary endpoint was the difference in serum 25(OH)D levels before and after six weeks of UV-LED exposure.
We found a statistically significant increase in serum 25(OH)D levels after six weeks of UV-LED exposure (P<0.001). Moreover, no severe adverse reactions were observed.
Based on the results obtained, the UV-LED device could be a potentially safe and effective way to treat vitamin D insufficiency.


Vitamin D; Females; Ultraviolet Light; Pilot Study
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