Ann Dermatol.  2015 Feb;27(1):10-14. 10.5021/ad.2015.27.1.10.

Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis

• Han TY
• Kong TS
• Kim MH
• Chae JD
• Lee JH
• Son SJ

• KMID: 2264830
• DOI: http://doi.org/10.5021/ad.2015.27.1.10

Abstract

BACKGROUND
Vitamin D insufficiency could be associated with the prevalence of atopic dermatitis (AD).
OBJECTIVE
To examine vitamin D status and the relations between serum 25-hydroxyvitamin D levels, SCORAD score, serum LL-37 level, and body mass index (BMI) in Korean AD patients, and to explore whether these associations differ between adults and children.
METHODS
Serum 25-hydroxyvitamin D levels, serum LL-37, and clinical features were analyzed in a total of 72 Korean patients with AD (39 adults and 33 children) and 140 healthy control subjects (70 adults and 70 children).
RESULTS
Serum 25-hydroxyvitamin D levels were significantly reduced in children with AD (15.06+/-4.64 ng/ml) compared with normal children in the control group (16.25+/-6.60 ng/ml) (p=0.036). Significant inverse correlations were found between BMI and 25-hydroxyvitamin D level (r=-0.315, p=0.007) and between the SCORAD score and serum LL-37 level (r=-0.3, p=0.011) in the total AD patients.
CONCLUSION
The results showed that serum vitamin D levels were lower in children with AD than in healthy children; however, the same relation was not observed between adults with AD and healthy adults. Serum 25-hydroxyvitamin D concentration was not significantly correlated with AD severity or serum LL-37 levels in our study population.

Keyword

25-Hydroxyvitamin D; Atopic dermatitis; LL-37; SCORAD

MeSH Terms

Adult*
Body Mass Index
Child*
Dermatitis, Atopic*
Humans
Prevalence
Vitamin D*
Vitamin D

Figure

• 

  Fig. 1 Mean serum 25-hydroxyvitamin D concentration in the atopic dermatitis (AD) and control groups. *p<0.05.

• 

  Fig. 2 Correlations between SCORAD, body mass index (BMI), vitamin D concentration, and serum LL-37 levels. Significant inverse correlations were found between BMI and vitamin D levels, and between SCORAD scores and serum LL-37 levels.

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