Int Neurourol J.
2021 Nov;25(Suppl 2):S47-54. 10.5213/inj.2142334.167.
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle
- Affiliations
-
- 1Department of Biomedical Science and Engineering, Inha University, Incheon, Korea
- 2Institute of Sports & Arts Convergence, Inha University, Incheon, Korea
- 3Department of Sport Science, Korea Institute of Sport Science, Seoul, Korea
- 4Department of Pharmacology, College of Medicine, Inha University, Incheon, Korea
- 5Department of Sport Science, Hannam University, Daejeon, Korea
- 6Department of Food and Nutrition, Hannam University, Daejeon, Korea
- 7Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
- 8Department of Counseling, Health, and Kinesiology, Texas A&M University at San Antonio, TX, USA
- KMID: 2522742
- DOI: http://doi.org/10.5213/inj.2142334.167
Abstract
- Purpose
The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated.
Methods
Female Sprague-Dawley rats were divided into control (CON), ovariectomy (OVX), and ovariectomy plus exercise (OVX+EX) groups. After ovarian excision, exercise training was performed using a rat treadmill at 20 m/min, 50 min/day, 5 days/week for 12 weeks. Protein levels of mitochondria-mediated apoptotic signaling and atrophy/hypertrophy signaling in the skeletal muscle (soleus) were examined through western immunoblot analysis.
Results
The number of myocytes and myocyte cross-sectional area (CSA) were increased and the extramyocyte space was decreased in the OVX group compared to those in the CON group. However, aerobic exercise training significantly increased myocyte CSA and decreased extramyocyte space in the OVX+EX group compared to those in the OVX group. The protein levels of proapoptotic signaling and muscle atrophy signaling were significantly increased, whereas the protein levels of muscle hypertrophy signaling were significantly decreased in the OVX group compared to that in the CON group. Aerobic exercise training significantly decreased the protein levels of proapoptotic signaling and increased the protein level of antiapoptotic protein in the OVX+EX group compared to that in the OVX group. Aerobic exercise training significantly increased the protein levels of hypertrophy signaling and decreased protein levels of atrophy signaling in the OVX+EX group compared to those in the OVX group.
Conclusions
Treadmill exercise improved estrogen deficiency-induced impairment in skeletal muscle remodeling, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in skeletal muscle.
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