J Bone Metab.  2021 Aug;28(3):179-191. 10.11005/jbm.2021.28.3.179.

Two Types of Mouse Models for Sarcopenia Research: Senescence Acceleration and Genetic Modification Models

Affiliations
  • 1Department of Physical Education, Gyeongsang National University, Jinju, Korea
  • 2Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Gyeongsang National University, Jinju, Korea
  • 3Biomedical Research Institute, Gyeongsang National University Hospital, Gyeongsang National University, Jinju, Korea
  • 4Department of Orthopaedic Surgery and Institute of Health Sciences, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Korea
  • 5Department of Convergence Medical Science, Gyeongsang National University, Jinju, Korea

Abstract

Sarcopenia leads to loss of skeletal muscle mass, quality, and strength due to aging; it was recently given a disease code (International Classification of Diseases, Tenth Revision, Clinical Modification, M62.84). As a result, in recent years, sarcopenia-related research has increased. In addition, various studies seeking to prevent and treat sarcopenia by identifying the various mechanisms related to the reduction of skeletal muscle properties have been conducted. Previous studies have identified muscle synthesis and breakdown; investigating them has generated evidence for preventing and treating sarcopenia. Mouse models are still the most useful ones for determining mechanisms underlying sarcopenia through correlations and interventions involving specific genes and their phenotypes. Mouse models used to study sarcopenia often induce muscle atrophy by hindlimb unloading, denervation, or immobilization. Though it is less frequently used, the senescence-accelerated mouse can also be useful for sarcopenia research. Herein, we discuss cases where senescence-accelerated and genetically engineered mouse models were used in sarcopenia research and different perspectives to use them.

Keyword

Aging; Mice; Muscle; skeletal; Sarcopenia
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