J Korean Biol Nurs Sci.  2021 Aug;23(3):247-255. 10.7586/jkbns.2021.23.3.247.

Differences in Body Weight, Dietary Efficiency, Brain Obesity Control Factor (AMPK), Reactive Oxygen Species (MDA), and Antioxidant Enzymes (SOD) in Young Mice According to the Intensity of Aerobic Exercise for 8 Weeks

• Jeon MY

• KMID: 2519515
• DOI: http://doi.org/10.7586/jkbns.2021.23.3.247

Abstract

Purpose
The goal of this study was to see how different aerobic exercise intensities affected AMP-activated protein kinase (AMPK), reactive oxygen, and antioxidant enzymes in young mice during an 8-week period.
Methods
Forty male C57BL/6 mice, aged seven weeks, were randomly assigned to one of four groups: control (n = 10), low-intensity exercise (n = 10), moderate-intensity exercise (n = 10), and high-intensity exercise (n = 10). For eight weeks, aerobic activity was performed once a day for 35–40 minutes, five days a week. The data were analyzed using descriptive statistics, analysis of variance (ANOVA), chi-squared tests, and the Tukey test in the SPSS/WIN 25.0 program.
Results
Weight (p = .001) was substantially different between the moderate-intensity exercise group and the control group in AMPK (p < .001). In addition, there were no significant differences between the moderate-intensity exercise group and the control group in reactive oxygen malondialdehyde (MDA) levels (p = .136) and antioxidant enzyme superoxide dismutase (SOD) levels (p = .521).
Conclusion
These findings suggest that moderate-intensity aerobic exercise increased AMPK activation and helped young mice shed weight.

Keyword

Antioxidants; AMP-activated protein kinases; Reactive oxygen species; Exercise; Mice