Clin Pediatr Hematol Oncol.  2021 Apr;28(1):49-53. 10.15264/cpho.2021.28.1.49.

Successful Treatment of Severe Hemolytic Disease of the Newborn Caused by Anti-Jk ^b

• Kim GL
• Kim Y
• Chang YP
• Seo JH
• Lee MJ

• KMID: 2515344
• DOI: http://doi.org/10.15264/cpho.2021.28.1.49

Abstract

Hemolytic disease of the newborn (HDN) is a condition in which maternal antibodies cross the placenta and cause hemolytic reactions. Anti-RhD was the most common cause, but with the introduction of immunoglobulin, the frequency has decreased sig nificantly, making hemolytic disease caused by other minor blood g roups more important. Kidd antigen is also known to cause hemolytic transfusion reactions. Only 13 cases have been reported so far, because Kidd antig en dose not usually cause HDN. Most cases have a good outcome, and only two fatal cases have been reported. A four-day-old male patient was hospitalized for jaundice, and hemolysis was confirmed by blood test. The mother’s blood was Jk^b antibody positive. The patient did not improve with phototherapy, so an exchange transfusion was performed. Additional hemolysis occurred, so we undertook transfusion of red blood cells, resulting in cessation of hemolysis. We report HDN caused by Jk^b antibody that responded to exchange blood transfusion.

Keyword

Hemolytic disease of the newborn; Jaundice; Exchange transfusion; Kidd blood group; Anti-Jk^b