Korean J Perinatol.  1998 Dec;9(4):425-428.

A Case of Hemolytic Disease of Newborn Caused by Anti=hr'(c)

• Lee KH
• Kim HW
• Park MC
• Lee YW

Abstract

Generally, the hemolytic disease of newborn caused by anti-c is characterized by the abnormal titer of anti-c in mother's serum and neonatal progressive jaundice caused by IgG induced hemolytic anemia. A female neonate delivered by cesarean section was admitted to Hangang Sacred Hospital due to severe jaundice and apnea on Jul. 7 1998. On admission, laboratory work up was revealed immune hemolytic anemia, but no incompatibility of ABO and Rh(D) system between mother and baby. Minor blood groups of mother and this second baby was ce and Cce. The serologic examination showed positive direct and indirect Coombs' test and the cause of jaundice was proved as the result of hemolytic disease due to anti-c via antibody screening and identification. After 2 times of exchange transfusion, the jaundice was subsided. So we reported a case of hemolytic disease due to anti-c with review of previous literatures.

Keyword

Immune hemoytic anemia; Minor blood group incompatibility; Anti-c isoimmunization

MeSH Terms

Anemia, Hemolytic
Apnea
Blood Group Antigens
Cesarean Section
Coombs Test
Erythroblastosis, Fetal*
Female
Humans
Immunoglobulin G
Infant, Newborn
Jaundice
Mass Screening
Mothers
Pregnancy
Blood Group Antigens
Immunoglobulin G