J Bone Metab.  2021 Feb;28(1):1-10. 10.11005/jbm.2021.28.1.1.

Comparison and Contrast of Bone and Dentin in Genetic Disorder, Morphology and Regeneration: A Review

  • 1College of Dental Medicine, Columbia University, New York, USA
  • 2Laboratory for the Study of Regenerative Dental Medicine, Department of Oral Histology-Developmental Biology & Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea


The bone and dentin have distinct healing processes. The healing process of bones is regenerative, as newly formed tissues are morphologically and functionally similar to the original bone structures. In contrast, the healing process of dentin is reparative due to its failure to replicate some of its key morphological features. In this review, we compare and contrast the healing processes of bone and dentin. We describe how distinct morphological and physiological structures of the 2 tissues translate into different signaling molecules, growth factors, and matrix protein secretion.


Bone and bones · Bone regeneration · Dentin · Dentinogenesis · Regeneration
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