Clin Exp Reprod Med.  2020 Dec;47(4):263-268. 10.5653/cerm.2020.04126.

Autophagy in the uterine vessel microenvironment: Balancing vasoactive factors

• Lim HJ

• KMID: 2509282
• DOI: http://doi.org/10.5653/cerm.2020.04126

Abstract

Autophagy, which has the literal meaning of self-eating, is a cellular catabolic process executed by arrays of conserved proteins in eukaryotes. Autophagy is dynamically ongoing at a basal level, presumably in all cells, and often carries out distinct functions depending on the cell type. Therefore, although a set of common genes and proteins is involved in this process, the outcome of autophagic activation or deficit requires scrutiny regarding how it affects cells in a specific pathophysiological context. The uterus is a complex organ that carries out multiple tasks under the influence of cyclic changes of ovarian steroid hormones. Several major populations of cells are present in the uterus, and the interactions among them drive complex physiological tasks. Mouse models with autophagic deficits in the uterus are very limited, but provide an initial glimpse at how autophagy plays a distinct role in different uterine tissues. Herein, we review recent research findings on the role of autophagy in the uterine mesenchyme in mouse models.

Keyword

Autophagy; Mesenchyme; Mice; Uterus; Vessel