Nat Prod Sci.  2020 Mar;26(1):59-63. 10.20307/nps.2020.26.1.59.

Biological Activity of Chemical Constituents Isolated from Strain Chlamydomonas sp. KSF108 (Chlamydomonadaceae)

• Tran HNK
• Youn UJ
• Kim M
• Cao TQ
• Kim JA
• Woo MH
• Kim S
• Min BS

• KMID: 2503926
• DOI: http://doi.org/10.20307/nps.2020.26.1.59

Abstract

This study focused on investigation of the immunosuppressive inhibitory effect through determination of IL-2 production of nine compounds (1 − 9) isolated from Chlamydomonas sp. KSF108. Among them, compounds 1, 5, and 6 displayed moderately inhibitory effects on IL-2 production at a concentration of 100 μM. In addition, the related ones including cytotoxic, anti-inflammatory, and anti-oxidant activities were also elucidated. 6 further displayed cytotoxic activity against the MCF-7 cell line, with an IC50 value of 17.2 μM and 4, 6 − 7, and 9 possessed significant DPPH radical scavenging activity, with IC50 values ranging from 3.1 to 4.4 μM. To the best of our knowledge, this is the first report on the bioactivity of isolated chemical constituents from the genus Chlamydomonas. Compounds 1 and 5 investigated for the first time in the activity of immunosuppressivity and 6 may come to serve as the most important marker in broad-spectrum activities of the secondary metabolites identified from C. sp. KSF108.

Keyword

Chlamydomonadaceae; Chlamydomonas sp. KSF108; Immunosuppressive; Anti-inflammatory; Cytotoxic; Anti-oxidant