Korean J Otorhinolaryngol-Head Neck Surg.  2020 Jan;63(1):26-30. 10.3342/kjorl-hns.2018.00605.

Impact of the Preoperative Neutrophil to Lymphocyte Ratio on Patients with Head and Neck Cancer

Affiliations
  • 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea

Abstract

Background and Objectives
To investigate the prognostic value of the neutrophil to lymphocyte ratio (NLR) in patients with head and neck squamous cell cancer (HNSCC). Subjects and Method Clinical data from 259 patients with HNSCC were collected retrospectively. NLR was adopted as potential prognostic biomarkers.
Results
NLR was associated with cancer recurrence (p=0.002 and p<0.001, respectively). Patients with a NLR >2.15 had significantly decreased 5-year disease specific survival (DSS) based on the Kaplan-Meier survival curves (p<0.001 and p=0.029, respectively). The Multivariate Cox regression analysis confirmed a significant association between 5-year DSS and the NLR (using 2.15 as the cut-off; hazard ratio, 1.852; 95% confidence interval, 1.237-2.771; p= 0.003).
Conclusion
A NLR cut-off value ≥2.15 was associated with adverse outcomes in patients with HNSCC.

Keyword

Head and neck neoplasms; Hematologic tests; Prognosis; Recurrence; Squamous cell carcinoma
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