Korean J Radiol.  2020 Apr;21(5):598-604. 10.3348/kjr.2019.0755.

Ultrasonographic Indeterminate Lymph Nodes inPreoperative Thyroid Cancer Patients: Malignancy Riskand Ultrasonographic Findings Predictive of Malignancy

Affiliations
  • 1Department of Radiology, Seoul National University Hospital, Seoul, Korea
  • 2Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
  • 3Department of Pathology, Seoul National University Hospital, Seoul, Korea
  • 4Department of Radiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea

Abstract


Objective
Proper management of lymph nodes (LNs) with ultrasonographic (US) indeterminate features in thyroid cancer patients remains elusive. We aimed to evaluate the malignancy risk and US findings predictive of malignancy for US indeterminate LNs in preoperative thyroid cancer patients through node-by-node correlation.
Materials and Methods
A total of 348 LNs in 284 thyroid cancer patients, who underwent fine-needle aspiration or coreneedle biopsy between December 2006 and June 2015, were included. We determined the malignancy risks for US probably benign, indeterminate, and suspicious categories. For US indeterminate LNs, which had neither echogenic hilum nor hilar vascularity in the absence of any suspicious finding, US findings were compared between benign and metastatic LNs using Mann-Whitney U test and Fisher’s exact test.
Results
US imaging diagnoses were probably benign in 20.7% (n = 72) cases, indeterminate in 23.6% (n = 82), and suspicious in 55.7% (n = 194). Malignancy risk of US indeterminate LNs (19.5% [16/82]) differed from those of the US probably benign (2.8% [2/72]) (p = 0.002) and US suspicious LNs (78.4% [152/194]) (p < 0.001). Among US indeterminate LNs, there were no significant differences in short, long, and long-to-short diameter (L/S) ratios between benign and metastatic LNs (3.9 vs. 3.8 mm, p = 0.619; 7.3 vs. 7.3 mm, p = 0.590; 1.9 vs. 1.9, p = 0.652).
Conclusion
US indeterminate LNs were frequently encountered during preoperative evaluation and had intermediate malignancy risk. Given the lack of discriminative power of size criteria and L/S ratio, clinical factors such as surgical strategy and node size should be considered for proper triage of US indeterminate LNs in thyroid cancer.

Keyword

Lymph nodes; Risk; Thyroid neoplasms; Triage; Ultrasonography
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