Korean J Radiol.  2020 Apr;21(4):505-508. 10.3348/kjr.2020.0146.

False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases

Affiliations
  • 1Department of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China. 724501143@qq.com
  • 2Institute of Advanced Research, Infervision, Beijing, China.
  • 3Department of Infection, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China.

Abstract

The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.

Keyword

COVID-19; SARS-COV-2; rRT-PCR; False-negative results; Laboratory examination; Computed tomography

MeSH Terms

Coinfection
Coronavirus*
Diagnosis*
Methods
Polymerase Chain Reaction*
Severe Acute Respiratory Syndrome*
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