Endocrinol Metab.  2020 Mar;35(1):1-6. 10.3803/EnM.2020.35.1.1.

Impact of Skeletal Muscle Mass on Metabolic Health

Affiliations
  • 1Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jaehyeon@skku.edu

Abstract

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diseases, including metabolic syndrome and non-alcoholic fatty liver disease.

Keyword

Muscle, skeletal; Sarcopenia; Metabolic syndrome; Non-alcoholic fatty liver disease

MeSH Terms

Adipose Tissue
Cardiovascular System
Liver
Metabolic Diseases
Motor Activity
Muscle, Skeletal*
Non-alcoholic Fatty Liver Disease
Pancreas
Sarcopenia
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