J Korean Orthop Assoc.  1974 Mar;9(1):74-80. 10.4055/jkoa.1974.9.1.74.

Clinical Observation on 48 Cases of Osteogenic Sarcoma

• Chun SY

• KMID: 2471601
• DOI: http://doi.org/10.4055/jkoa.1974.9.1.74

Abstract

Osteogenic Sarcoma is a malignant tumor arising from the undifferentiated fibrous tissue of bone, and one of the most common primary malignant tumors of bone. Clinical observation was carried out on 48 cases of osteogenic sarcoma which were experienced at the Department of Orthopedic Surgery, College of Medicine, Seoul National University from Nov. 1958 till Jun. 1973. The results were summarized as follows: 1. Osteogenic sarcoma was the most frequently encountered malignant bone tumor, consisting of 59.3% of the cases of primary malignant tumor of bone. 2. The peak incidence was in the age group from 11 to 20 years in 25 cases (52.1%). 3. The sex distribution was 29 in males and 19 in females. 4. The most commonly affected site was distal femur (33.3%), and 29 cases(58.3%) were around the knee. 5. Increment of serum alkaline phosphatase was observed in 22 cases (45.8%), and the average value of serum alkaline phosphatase in these cases was 12.2 Bodansky units. 6. The histopathological study revealed osteoblastic type in 23 cases (52.3%), fibroblastic in 10 cases (22.7%), and chondroblastic in 9 cases (20.5%). 7. Among 48 cases of osteogenic sarcoma, amputation was done in 21 (43.8%), and irradiation in 2 cases. Chemotherapy was done in a case. 21 cases refused amputation and discharged. 8. Follow-up study for 18 months was done in 22 cases: 15 cases died within a year after discharge by pulmonary metastasis, 7 cases survived. A patient who had hindquarter amputation survived more than 10 years.

MeSH Terms

Alkaline Phosphatase
Amputation
Chondrocytes
Drug Therapy
Female
Femur
Fibroblasts
Follow-Up Studies
Humans
Incidence
Knee
Male
Neoplasm Metastasis
Orthopedics
Osteoblasts
Osteosarcoma*
Seoul
Sex Distribution
Alkaline Phosphatase

Reference

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