Ann Hepatobiliary Pancreat Surg.  2020 Feb;24(1):1-5. 10.14701/ahbps.2020.24.1.1.

Hepatobiliary and pancreatic surgery in the elderly: Current status

Affiliations
  • 1General Surgery Unit, Del Mare Hospital, Naples, Italy. davide.papis@gmail.com
  • 2General Surgery Unit, Santa Maria delle Croci Hospital, Ravenna, Italy.

Abstract

Hepato-pancreatico-biliary (HPB) surgery includes major hepatic resection and pancreatic surgery, both procedures are complex and have a potentially high complication rate. The presence of centers of excellence with a high patients volume has lowered the complication and increased the resection rate. Increased life expectancy and improved general health status have increased the number of elderly patients eligible for major surgery. Since old patients have more co-morbidities and decreased life expectancy, the benefit of these procedures need to be critically evaluated in this group. Analysis of the literature related to this argument demonstrated that pancreatoduodenectomy can be performed safely in selected elderly patients (70 years of age or older), with morbidity and mortality rates comparable those observed in younger patients. This aspect was also confirmed by cost analysis studies that reported similar data in both groups. Similar findings are also reported for major hepatic resection in elderly patients with either hepatocellular carcinoma (HCC), Klatskin tumor or gallbladder carcinoma. More studies are needed regarding the subgroup of very elderly patients (80 years or older). Nevertheless, those elderly patients who will benefit from surgery must be adequatelly selected.

Keyword

Liver; Pancreas; Surgery; Elderly

MeSH Terms

Aged*
Carcinoma, Hepatocellular
Costs and Cost Analysis
Gallbladder
Humans
Klatskin Tumor
Life Expectancy
Liver
Mortality
Pancreas
Pancreaticoduodenectomy

Cited by  1 articles

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Reference

1. Adam R, Frilling A, Elias D, Laurent C, Ramos E, Capussotti L, et al. LiverMetSurvey Centres. Liver resection of colorectal metastases in elderly patients. Br J Surg. 2010; 97:366–376. PMID: 20101645.
Article
2. Demols A, Maréchal R, Devière J, Van Laethem JL. The multidisciplinary management of gastrointestinal cancer. Biliary tract cancers: from pathogenesis to endoscopic treatment. Best Pract Res Clin Gastroenterol. 2007; 21:1015–1029. PMID: 18070701.
3. DiCarlo V, Balzano G, Zerbi A, Villa E. Pancreatic cancer resection in elderly patients. Br J Surg. 1998; 85:607–610. PMID: 9635804.
4. Connor S, Sakowska M. Age and pancreaticoduodenctomy: is it really about mortality? HPB (Oxford). 2012; 14:647–648. PMID: 22953999.
Article
5. PACE participants. Audisio RA, Pope D, Ramesh HS, Gennari R, van Leeuwen BL, et al. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG surgical task force prospective study. Crit Rev Oncol Hematol. 2008; 65:156–163. PMID: 18082416.
6. Bonow RO, Masoudi FA, Rumsfeld JS, Delong E, Estes NA 3rd, Goff DC Jr, et al. American College of Cardiology. American Heart Association Task Force on Performance Measures. ACC/AHA classification of care metrics: performance measures and quality metrics: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. J Am Coll Cardiol. 2008; 52:2113–2117. PMID: 19056002.
7. Riffat F, Chu F, Morris DL. Liver resection in octogenarians. HPB (Oxford). 2006; 8:206–210. PMID: 18333278.
Article
8. Sarno G, Poston GJ. Liver surgery in elderly patients. In : Poston GJ, D'Angelica M, Adam R, editors. Surgical management of hepatobiliary and pancreatic disorders. 2nd ed. London: Informa Healthcare;2010. p. 46–52.
9. Huang J, Li BK, Chen GH, Li JQ, Zhang YQ, Li GH, et al. Long-term outcomes and prognostic factors of elderly patients with hepatocellular carcinoma undergoing hepatectomy. J Gastrointest Surg. 2009; 13:1627–1635. PMID: 19506976.
Article
10. Menon KV, Al-Mukhtar A, Aldouri A, Prasad RK, Lodge PA, Toogood GJ. Outcomes after major hepatectomy in elderly patients. J Am Coll Surg. 2006; 203:677–683. PMID: 17084329.
Article
11. Kondo K, Chijiiwa K, Funagayama M, Kai M, Otani K, Ohuchida J. Hepatic resection is justified for elderly patients with hepatocellular carcinoma. World J Surg. 2008; 32:2223–2229. PMID: 18642042.
Article
12. Ijtsma AJ, Boevé LM, van der Hilst CS, de Boer MT, de Jong KP, Peeters PM, et al. The survival paradox of elderly patients after major liver resections. J Gastrointest Surg. 2008; 12:2196–2203. PMID: 18651195.
Article
13. Wu CC, Chen JT, Ho WL, Yeh DC, Tang JS, Liu TJ, et al. Liver resection for hepatocellular carcinoma in octogenarians. Surgery. 1999; 125:332–338. PMID: 10076619.
Article
14. de Liguori Carino N, van Leeuwen BL, Ghaneh P, Wu A, Audisio RA, Poston GJ. Liver resection for colorectal liver metastases in older patients. Crit Rev Oncol Hematol. 2008; 67:273–278. PMID: 18595728.
Article
15. Cho SW, Steel J, Tsung A, Marsh JW, Geller DA, Gamblin TC. Safety of liver resection in the elderly: how important is age? Ann Surg Oncol. 2011; 18:1088–1095. PMID: 21046265.
Article
16. Onoyama H, Ajiki T, Takada M, Urakawa T, Saitoh Y. Does radical resection improve the survival in patients with carcinoma of the gallbladder who are 75 years old and older? World J Surg. 2002; 26:1315–1318. PMID: 12297924.
Article
17. di Sebastiano P, Festa L, Büchler MW, di Mola FF. Surgical aspects in management of hepato-pancreatico-biliary tumours in the elderly. Best Pract Res Clin Gastroenterol. 2009; 23:919–923. PMID: 19942168.
Article
18. Riall TS. What is the effect of age on pancreatic resection? Adv Surg. 2009; 43:233–249. PMID: 19845182.
Article
19. Sukharamwala P, Thoens J, Szuchmacher M, Smith J, DeVito P. Advanced age is a risk factor for post-operative complications and mortality after a pancreaticoduodenectomy: a meta-analysis and systematic review. HPB (Oxford). 2012; 14:649–657. PMID: 22954000.
20. Sulpice L, Rayar M, D'Halluin PN, Harnoy Y, Merdrignac A, Bretagne JF, et al. Impact of age over 75 years on outcomes after pancreaticoduodenectomy. J Surg Res. 2012; 178:181–187. PMID: 22541064.
Article
21. Suzuki S, Kaji S, Koike N, Harada N, Suzuki M. Pancreaticoduodenectomy can be safely performed in the elderly. Surg Today. 2013; 43:620–624. PMID: 23104552.
Article
22. Riall TS, Sheffield KM, Kuo YF, Townsend CM Jr, Goodwin JS. Resection benefits older adults with locoregional pancreatic cancer despite greater short-term morbidity and mortality. J Am Geriatr Soc. 2011; 59:647–654. PMID: 21453378.
Article
23. Bathe OF, Levi D, Caldera H, Franceschi D, Raez L, Patel A, et al. Radical resection of periampullary tumors in the elderly: evaluation of long-term results. World J Surg. 2000; 24:353–358. PMID: 10658072.
Article
24. Shamali A, De'Ath HD, Jaber B, Abuawad M, Barbaro S, Hamaday Z, et al. Elderly patients have similar short term outcomes and five-year survival compared to younger patients after pancreaticoduodenectomy. Int J Surg. 2017; 45:138–143. PMID: 28782662.
Article
25. Melis M, Marcon F, Masi A, Pinna A, Sarpel U, Miller G, et al. The safety of a pancreaticoduodenectomy in patients older than 80 years: risk vs benefits. HPB (Oxford) . 2012; 14:583–588. PMID: 22882194.
Article
26. Makary MA, Winter JM, Cameron JL, Campbell KA, Chang D, Cunningham SC, et al. Pancreaticoduodenectomy in the very elderly. J Gastrointest Surg. 2006; 10:347–356. PMID: 16504879.
Article
27. Parmar AD, Vargas GM, Tamirisa NP, Sheffield KM, Riall TS. Trajectory of care and use of multimodality therapy in older patients with pancreatic adenocarcinoma. Surgery. 2014; 156:280–289. PMID: 24851723.
Article
28. Lu Q, Lu JW, Wu Z, Liu XM, Li JH, Dong J, et al. Perioperative outcome of elderly versus younger patients undergoing major hepatic or pancreatic surgery. Clin Interv Aging. 2018; 13:133–141. PMID: 29416321.
Article
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