Int J Oral Biol.  2019 Dec;44(4):144-151. 10.11620/IJOB.2019.44.4.144.

Effect of the hedgehog signaling pathway on hair formation-related cells

Affiliations
  • 1Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Republic of Korea. sangho@snu.ac.kr
  • 2Biomedical Research Institute, NeoRegen Biotech Co. Ltd., Suwon 16614, Korea.

Abstract

Alopecia has emerged as one of the biggest interests in modern society. Many studies have focused on the treatment of alopecia, such as transplantation of hair follicles or inhibition of the androgen pathway. Hair growth is achieved through proper proliferation of the components such as keratinocytes and dermal papilla cells (DPCs), movement, and interaction between the two cells. The present study examined the effect of the hedgehog (Hh) signaling pathway, which is an important and fundamental signal in the cell, on the morphology and the viability of human keratinocytes and DPCs. Upregulation of Hh signaling caused a morphological change and an increase in epithelium-mesenchymal transition-related gene expression but reduced the viability of keratinocytes, while the alteration of Hh signaling did not cause any change in DPCs. The results show the possibility that the regulation of Hh signaling can be applied for the treatment of alopecia.

Keyword

Keratinocytes; Dermal papilla cell; Hedgehog signaling; Epithelial-mesenchymal transition
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