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Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

Choi YK, Kang JI, Hyun JW, Koh YS, Kang JH, Hyun CG, Yoon KS, Lee KS, Lee CM, Kim TY, Yoo ES, Kang HK

Alopecia is a distressing condition caused by the dysregulation of anagen, catagen, and telogen in the hair cycle. Dermal papilla cells (DPCs) regulate the hair cycle and play important roles...
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Effect of Chrysanthemum zawadskii Extract on Dermal Papilla Cell Proliferation and Hair Growth

Kim YD, Pi LQ, Lee WS

Background: Chrysanthemum zawadskii (CZ) belongs to the genus Chrysanthemum, also known as ‘Gu-Jeol-Cho’ in Korea. CZ has been used as herbal remedy to manage cough, hypertensive disorders, pharyngitis, bronchitis, gastroenteritis,...
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Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell

Nilforoushzadeh MA, Aghdami N, Taghiabadi E

BACKGROUND: Hair loss is a prevalent medical problem in both men and women. Maintaining the potential hair inductivityof dermal papilla cells (DPCs) during cell culture is the main factor in...
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Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells

Kang JI, Choi YK, Koh YS, Hyun JW, Kang JH, Lee KS, Lee CM, Yoo ES, Kang HK

The hair cycle (anagen, catagen, and telogen) is regulated by the interaction between mesenchymal cells and epithelial cells in the hair follicles. The proliferation of dermal papilla cells (DPCs), mesenchymal-derived...
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Effect of the hedgehog signaling pathway on hair formation-related cells

Park J, Park S, Seo J, Roh S

Alopecia has emerged as one of the biggest interests in modern society. Many studies have focused on the treatment of alopecia, such as transplantation of hair follicles or inhibition of...
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Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

Oh JH, Jeong KH, Kim JE, Kang H

BACKGROUND: The ceramide is known to play an important role in the formation of intracellular lipids, and play a crucial role as a barrier for skin and hair cuticle. Recent...
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Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth

Bak DH, Choi MJ, Kim SR, Lee BC, Kim JM, Jeon ES, Oh W, Lim ES, Park BC, Kim MJ, Na J, Kim BJ

Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of...
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Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways

Joo HJ, Jeong KH, Kim JE, Kang H

BACKGROUND: The human dermal papilla cells (hDPCs) play an important role in regulation of hair cycling and growth. OBJECTIVE: The aim of this study was to investigate the effect of different...
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11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

Lee SE, Lee EY, Kang SJ, Lee SH

PURPOSE: Glucocorticoids, stress-related hormones, inhibit hair growth. Intracellular glucocorticoid availability is regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD1 was recently detected in keratinocytes and fibroblasts. However, the expression of...
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3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

Kim YE, Choi HC, Lee IC, Yuk DY, Lee H, Choi BY

3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle...
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Synergistic Proliferating Effects of Electrical Stimulation and Minoxidil on Human Dermal Papilla Cells

Woo YJ, Jeong KH, Kim JE, Kang H

  • KMID: 2382988
  • Korean J Dermatol.
  • 2016 Jun;54(5):341-349.
BACKGROUND: Previous published clinical studies have demonstrated the positive effects of electrical stimulation (ES) on hair growth. Minoxidil (MXD) enhances hair growth by prolonging the anagen phase of hair follicles....
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Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

Shin S, Kim K, Lee MJ, Lee J, Choi S, Kim KS, Ko JM, Han H, Kim SY, Youn HJ, Ahn KJ, An IS, An S, Cha HJ

BACKGROUND: Dihydrotestosterone (DHT) induces androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. We previously demonstrated how changes in the microRNA (miRNA) expression profile influenced DHT-mediated...
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Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

Rastegar H, Ashtiani H, Aghaei M, Barikbin B, Ehsani A

BACKGROUND: The number of people suffering from balding or hair thinning is increasing, despite the advances in various medical therapies. Therefore, it is highly important to develop new therapies to...
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Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues

Choi SH, Moon JS, Jeon BS, Jeon YJ, Yoon BI, Lim CJ

BP201, porcine lung tissue-derived phospholipids, consists of phosphatidylcholine as a major phospholipid species. BP201 promoted hair growth after application onto the shaved backs of BALB/c and C3H mice. Its effect...
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Promotive Effect of Minoxidil Combined with All-trans Retinoic Acid (tretinoin) on Human Hair Growth in Vitro

Kwon OS, Pyo HK, Oh YJ, Han JH, Lee SR, Chung JH, Eun HC, Kim KH

Minoxidil induces hair growth in male pattern baldness and prolongs the anagen phase. All-trans retinoic acid (ATRA) has been reported to act synergistically with minoxidil in vivo: they can enhance...
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The Effect of Medications Used in Mesotherapy on Hair Organ Culture and Culture of Dermal Papilla Cells

Lee WJ, Choe YS, Lee JC, Lee SJ, Kim DW, Min PK

  • KMID: 1891773
  • Korean J Dermatol.
  • 2006 Oct;44(10):1178-1185.
BACKGROUND: Hair loss including androgenetic alopecia and chronic telogen effluvium is recognized increasingly as a physically and psychologically harmful medical condition. Mesotherapy is considered as a new therapeutic modality for...
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Effects of Calcitonin Gene-Related Peptide on the Hair Growth in Human Hair Follicle Organ Culture

Oh TH, Lee EY, Lee S, Lee WS

  • KMID: 2302672
  • Korean J Dermatol.
  • 2005 Mar;43(3):342-351.
BACKGROUND: It has recently been reported that the peripheral nervous system has an important role in the hair growth and hair cycle change, which is mediated by neuropeptides. Furthermore, the...
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Effects of Substance P on the Expression of Various Factors to control Hair Growth in Human Hair Follicle Culture

Oh TH, Lee EY, Lee WS

  • KMID: 1605839
  • Korean J Dermatol.
  • 2004 Dec;42(12):1543-1551.
BACKGROUND: Among constituents of the skin, hair follicle is an organ where nerve fibers with the most highest density are distributed. Recently, it has been reported that neuropeptides, which are...
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Effects of Vaseular Endothelial Growth Factors on Hair Growth in Vitro

Back SH, Yoon JB, Sim WY, Haw CR

  • KMID: 1548196
  • Korean J Dermatol.
  • 1999 Jan;37(1):23-30.
BACKGROUND: It has been suggested that the regulation of hair growth might involve complex interaction between dermal papilla cells and hair matrix cells. Dermal papilla cells secrete diffusible factors that...
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Effects of Alopecia Areata Serum on Proliferation of Cultured Dermal Papilla Cells

Lee SJ, Cho YH, Sim WY, Haw CR

  • KMID: 2230529
  • Korean J Dermatol.
  • 1998 Dec;36(6):1032-1036.
BACKGROUND: Dermal papilla cells, which are mesenchymal components of the hair bulb are considered to play an important role in the regulation of hair growth by production of diffusible factors...
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