Soonchunhyang Med Sci.
2019 Dec;25(2):155-158. 10.0000/sms.2019.25.2.155.
Deferiprone Related Arthropathy in 11-Year-Old Boy with Hereditary Spherocytosis
- Affiliations
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- 1Department of Pediatrics, Soonchunhyang University College of Medicine, Cheonan, Korea. kbpark@schmc.ac.kr
- 2Department of Radiology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
- KMID: 2470422
- DOI: http://doi.org/10.0000/sms.2019.25.2.155
Abstract
- Regular transfusion therapy in children with intractable hematologic disorder results in hemosiderosis. It causes several organ damages such as liver, heart, and endocrine system and increases risk of infection. Thus, iron-chelating therapy is essential to promote normal development, prevent excess iron overload and death in children. In abroad, deferiprone has been approved for use in thalassemic children with transfusion induced iron overload. Side effects associated with deferiprone include agranulocytosis, arthropathy, gastrointestinal symptoms, increased alanine aminotransferase levels, and zinc deficiency. Arthropathy has been reported to occur approximately 9%-38% of patients. We present an 11-year-old boy patient with hereditary spherocytosis, who experienced arthropathy while under deferiprone therapy.
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