Mycobiology.  2019 Dec;47(4):449-456. 10.1080/12298093.2019.1651592.

Identification and Antifungal Susceptibility Profiles of Cyberlindnera fabianii in Korea

• Park JH
• Oh J
• Sang H
• Shrestha B
• Lee H
• Koo J
• Cho SI
• Choi JS
• Lee MH
• Kim J
• Sung GH

• KMID: 2470177
• DOI: http://doi.org/10.1080/12298093.2019.1651592

Abstract

Invasive fungal infections caused by Cyberlindnera fabianii have recently increased. However, biochemical kits such as API 20 C AUX and Vitek-2C have misidentified this species as other Candida spp. such as C. pelliculosa or C. utilis due to no information of Cy. fabianii in yeast database. During our 2016-2017 surveys, eleven isolates of Cy. fabianii were obtained in International St. Mary's Hospital in Korea. Here, we describe its morphological and molecular characteristics and tested its antifungal susceptibility against nine antifungal agents. The sequences of the ITS region and the D1/D2 region of LSU revealed 100% identity with the sequences of Cy. fabianii. In comparison with the results from MALDI-TOF mass spectrometry, we found that Cy. fabianii can be distinguished from other species. In antifungal susceptibility test, voriconazole and echinocandins exhibited good antifungal activities against the majority of Cy. fabianii isolates despite the absence of standard criteria.

Keyword

Antifungal susceptibility test; Cyberlindnera fabianii; MALDI-TOF MS; MIC; phylogenetic analysis

MeSH Terms

Antifungal Agents
Candida
Echinocandins
Korea*
Mass Spectrometry
Voriconazole
Yeasts
Antifungal Agents
Echinocandins
Voriconazole