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Voriconazole-refractory invasive aspergillosis

Park SY, Yoon JA, Kim SH

Invasive aspergillosis (IA) is one of the most common life-threatening complications in immunocompromised patients. Voriconazole is currently the drug of choice for IA treatment. However, some patients with IA suffer...
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Invasive Aspergillosis Complicated by Occlusion of Internal Carotid Artery and Cerebral Infarction

Lee E, Lee S, Park HI, Chun W, Park HK

Invasive aspergillosis is one of rare causes of mortality for the immune-compromised patients. We present a case of invasive aspergillosis complicated by the occlusion of the internal carotid artery and...
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Validation of Voriconazole Therapeutic Drug Monitoring in Lung Transplant Recipients Receiving Voriconazole alone for Treatment of Invasive Aspergillosis

Son YJ, Lee KA, Jo JH, Kim JS, Son ES, Park MS

BACKGROUND: Invasive aspergillosis (IA) is associated with high morbidity and mortality, particularly among immunocompromised patients, such as lung transplant recipients. Voriconazole, the first-line therapy for IA, shows a non-linear pharmacokinetic...
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Effect of Voriconazole or Itraconazole on the Plasma Concentrations of Tacrolimus in Lung Transplant Recipients

Jung YJ, Yi YS, Ahn JH, Son ES, Park MS, Lee JI, Chang MJ

OBJECTIVE: This study was performed to compare the changes in the blood concentrations of tacrolimus when either itraconazole or voriconazole is together with tacrolimus to prevent or treat invasive aspergillus...
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A Case of Multiple Fungal Abscesses on Inguinal Area Caused by Itraconazole-resistant Trichophyton rubrum

Kang HJ, Won CH, Chang SE, Lee MW, Choi JH, Lee WJ

  • KMID: 2388336
  • Korean J Dermatol.
  • 2017 Jul;55(6):360-363.
Dermatophytes usually infect keratinized epithelial structures such as hair and nails. However, they can also cause deep and extensive fungal infections, especially in immunocompromised patients. We report a case with...
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Fungal Infection in Patients with Diabetes Mellitus

Yun NR

Diabetes mellitus is a major risk factor for fungal infections, and mortality increases when diagnosis and treatment of fungal infections are delayed in diabetic patients. Common fungal infections in diabetic...
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Infectious Crystalline Keratopathy Caused by Alternaria

Hong HJ, Yun JM, Park DJ

PURPOSE: To report a case of infectious crystalline keratopathy caused by Alternaria in the corneal center. CASE SUMMARY: A 66-year-old male visited our clinic with right ocular pain and visual loss...
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Voriconazole plus caspofungin for treatment of invasive fungal infection in children with acute leukemia

Lee KH, Lim YT, Hah JO, Kim YK, Lee CH, Lee JM

BACKGROUND: Invasive fungal infections (IFIs) are a life-threatening problem in immunocompromised patients. Despite timely diagnosis and appropriate antifungal therapy, clinical outcomes of IFIs remain unsatisfactory, necessitating treatment with a combination...
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Catheter-Related Trichosporon asahii Bloodstream Infection in a Neutropenic Patient with Myelodysplastic Syndrome

Go SE, Lee KJ, Kim Y, Choi JK, Kim YJ, Lee DG

Because primary antifungal prophylaxis is widely used for immunocompromised hosts, the incidences of unusual fungal infections have increased. Trichosporon asahii has emerged as an important life-threatening opportunistic systemic pathogen because...
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Paradoxical Response after a Voriconazole Treatment in an Immunocompetent Host with a Skull Base Osteomyelitis due to Invasive Aspergillosis

Kim JM, Jung HB, Bae JH, Choi SH, Lee TJ

BACKGROUND: We describe a case of skull base osteomyelitis due to invasive aspergillosis which had been aggravated after antifungal treatment but significantly recovered by dexamethasone. CASE REPORT: A 74-year-old male patient...
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A Case of Fungal Endophthalmitis after Having Received Extraction of Wisdom Tooth in Healthy Woman

Lee M, Choi EY, Lee SC, Kim M

PURPOSE: To report a case of candida endogenous endophthalmitis in healthy women who had received extraction of wisdom tooth. CASE SUMMARY: A 65-year-old medically healthy woman who had received extraction of...
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Kodamaea ohmeri Fungemia in a Patient with Carcinoma of the Ampulla of Vater

Son BR, Shin KS

Kodamaea ohmeri, previously known as Pichia ohmeri or Yamadazyma ohmeri, is an ascosporogenous yeast that belong to the Saccharomycetaceae family, and it is a rare yeast-form fungus recently identified as...
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Keratitis Caused by Paecilomyces lilacinus after Cataract Surgery in a Patient with Systemic and Autoimmune Disease

Oh SY, Kang HS, Lee CK

PURPOSE: To report a case of Paecilomyces lilacinus fungal keratitis after cataract surgery in a patient with chronic systemic and autoimmune disease who was treated with medical therapy and penetrating...
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A Case of Therapeutic Keratoplasty Using Cryo-preservative Cornea in Candida albicans Keratitis

Han JY, Jun JH

PURPOSE: To report a case treated with therapeutic keratoplasty using a cryo-preserved cornea in a patient with Candida albicans keratitis. CASE SUMMARY: A 77-year-old female visited our clinic because of left...
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Fungal Keratitis Caused by Corynespora cassiicola, a Plant Pathogen

Chung SR, Lee HS, You IC

A 74-year-old man presented with pain and progressively worsening vision from 20 days ago in the left eye. His ophthalmological history was significant for cataract extraction, scleromalacia, and three surgeries...
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A Case of Fungal Keratitis Caused by Purpureocillium lilacinum: A Microbiological Review of Korean Cases

Kim J, Kim D, Jang J, Sung H, Kim MN

Purpureocillium(P) lilacinum is a ubiquitous, saprophytic filamentous fungus that is infrequently reported in keratitis and cutaneous infections. However, the microbiological characterization of the culture isolates is limited in Korea. A...
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Identification and Antifungal Susceptibility Profiles of Cyberlindnera fabianii in Korea

Park JH, Oh J, Sang H, Shrestha B, Lee H, Koo J, Cho SI, Choi JS, Lee MH, Kim J, Sung GH

Invasive fungal infections caused by Cyberlindnera fabianii have recently increased. However, biochemical kits such as API 20 C AUX and Vitek-2C have misidentified this species as other Candida spp. such...
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Species Distribution and Antifungal Susceptibility of Yeasts Isolated from Ear Specimens

Kwon YJ, Byun SA, Choi MJ, Won EJ, Kim SH, Shin JH

BACKGROUND: Candida auris was first isolated from the ears of Japanese and Korean patients. However, the prevalence of yeast isolates from ear cultures and their antifungal susceptibility profiles in these...
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Development of a simple and sensitive HPLC-MS/MS method for determination of diazepam in human plasma and its application to a bioequivalence study

Kim DH, Cho JY, Chae SI, Kang BK, An TG, Shim WS, Noh YS, Hwang SJ, Chung EK, Lee KT

We developed a simple, sensitive, and effective ultra-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) method with an electrospray ionization (ESI) interface in multiple reaction monitoring (MRM) and positive ion modes to...
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Polymicrobial Keratitis of Pseudomonas aeruginosa, Acinetobacter baumannii, and Ochrobactrum anthropi

Kang JY, Song JH, Nam KY, Lee SU, Lee SJ

PURPOSE: To report polymicrobial keratitis involving Pseudomonas aeruginosa, Acinetobacter baumannii, and Ochrobactrum anthropi. CASE SUMMARY: A 53-year-old female complained of pain and secretion in her right eye, which started 6 weeks...
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